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G-CSF Instillation Procedure

What is the G-CSF Instillation Procedure (GIP)? 

An intrauterine G-CSF instillation procedure (GIP) involves the injection into the uterine cavity of Nivestim™ in a procedure that is technically the same as an intrauterine insemination procedure and very similar to an embryo transfer procedure  

It is thought that conception is less likely to occur in patients where the uterine lining (endometrium) is less than 7mm thick.  A GIP can be used to impove endometrial thickness and quality when other interventions have not proved successful.   

What is G-CSF?

Granulocyte Colony Stimulating Factor (G-CSF) is a glycoprotein growth factor. Its primary function is to act on bone marrow cells via surface receptors and causes their growth and development. 

It is also produced by fallopian tube and uterine cells and G-CSF receptors have been identified on the surface of egg cells. These findings prompted investigations that have shown its use to be of benefit in the treatment of implantation failure following IVF, recurrent miscarriage and poor development of the lining of the uterus during assisted reproduction treatment cycles that is resistant to other treatments. 

Clinical trials using G-CSF as a treatment for thin endometrium have reported a clinically significant effect within 48 hours of administration.  

Who is a G-CSF Instillation Procedure (GIP) suitable for? 

At Fertility North, GIP is used to treat patients who have experienced: 

  • Treatment of implantation failure following IVFICSI and FET. 
  • Recurrent miscarriage. 
  • Poor development of the lining of the uterus during fertility treatment cycles that other therapies have failed to alleviate. 

How can we help you?

At Fertility North, we have been offering treatment with a form of G-CSF, called Nivestim™, since 2017.  

While a GIP has been shown to help some patients in conceiving, it is not suitable for use in all patients.  Our Fertility Doctors would be happy to discuss whether GIP may be of benefit to you.  To arrange an appointment or to find out more, please contact the team at Fertility North.