Advanced Technology

G-CSF Instillation Procedure (GIP) 

A GIP is the carefully timed introduction of growth factors into the uterine cavity to improve outcomes in selected groups of patients.  

What is the G-CSF Instillation Procedure (GIP)?  

An intrauterine G-CSF instillation procedure (GIP) involves the injection into the uterine cavity of Filgrastim, which is a copy of a substance normally present in your body, called Granulocyte Colony Stimulating Factor or G-CSF.  G-CSF acts to encourage cell growth.

A GIP takes place during a procedure that is technically the same as an intrauterine insemination procedure, and very similar to an embryo transfer procedure. 

What is G-CSF? 

Granulocyte Colony Stimulating Factor (G-CSF) is a glycoprotein growth factor. Its primary function is to act on bone marrow cells via surface receptors and causes their growth and development.  

It is also produced by fallopian tube and uterine cells and G-CSF receptors have been identified on the surface of egg cells. These findings prompted investigations that have shown its use to be of benefit in the treatment of implantation failure following IVF, recurrent miscarriage and poor development of the lining of the uterus during assisted reproduction treatment cycles that is resistant to other treatments.  

Clinical trials using G-CSF as a treatment for thin endometrium have reported a clinically significant effect within 48 hours of administration.   

Why use GIP? 

It is thought that conception is less likely to occur in patients where the uterine lining (endometrium) is less than 7mm thick.  A GIP can be used to impove endometrial thickness and quality when other interventions have not proved successful. 

Who is a G-CSF Instillation Procedure (GIP) suitable for? 

At Fertility North, GIP is used to treat patients who have experienced:  

  • Treatment of implantation failure following IVF, ICSI and FET.  
  • Recurrent miscarriage.  
  • Poor development of the lining of the uterus during fertility treatment cycles that other therapies have failed to alleviate. 

How can we help you?  

At Fertility North, we have been offering treatment with a form of G-CSF, Filgastrim, since 2017.   

While a GIP has been shown to help some patients in conceiving, it is not suitable for use in all patients.  Our Fertility Doctors would be happy to discuss whether GIP may be of benefit to you.  To arrange an appointment or to find out more, please contact the team at Fertility North. 

Contact Us